The First Human MAb developed specific for PMP22.
Research tool for:
Peripheral Myelin Protein 22 (PMP22) is a 160 amino acid glycoprotein which is a member of the claudin family and is thought to play an important role in the structure of peripheral nerve myelin. Irregularities in its gene results in hereditary demyelinating neuropathies. PMP22 protein is present in the compact myelin of adult human peripheral nerve and its distribution mimics that of Myelin Protein zero (P0).
Product Type
Hybridoma for monoclonal antibody
Immunogen
Human PMP22 cDNA boosted with 13-mer peptide of the secondextracellular domain of PMP22
CrossReactivity
Cross-reacts with rhesus monkey. (NOT with mouse, bovine&ratnerve)
Specificity
Detects residues 121-123 in the second extracellular domain of humanPMP22.
Raised in
Balb/CMice
Isotype
IgG1
References