Human PMP22 Monoclonal Antibody

The First Human MAb developed specific for PMP22.

 

Research tool for:

  • Western blotting
  • Immunohistochemistry – paraffin sections
  • ELISA

 

 

 

Peripheral Myelin Protein 22 (PMP22) is a 160 amino acid glycoprotein which is a member of the claudin family and is thought to play an important role in the structure of peripheral nerve myelin. Irregularities in its gene results in hereditary demyelinating neuropathies. PMP22 protein is present in the compact myelin of adult human peripheral nerve and its distribution mimics that of Myelin Protein zero (P0).

 

Product Type

Hybridoma for monoclonal antibody


Immunogen

Human PMP22 cDNA boosted with 13-mer peptide of the secondextracellular domain of PMP22


CrossReactivity

Cross-reacts with rhesus monkey. (NOT with mouse, bovine&ratnerve)


Specificity

Detects residues 121-123 in the second extracellular domain of humanPMP22.


Raised in

Balb/CMice


Isotype

IgG1

 

References

  1. Gregson NA, Zhang G, Pritchard J, Wang A, Sanvito L, Hayday AC,Hughes RAC. 2007. Characterization of amonoclonal antibody specific for human peripheral myelin protein 22 and its usein immunohistochemical studies of the fetal and adult nervous system. J Peripheral Nervous System. 12:2–10 (2007).
Patent Information:
For Information, Contact:
Melissa Rubock
IP & Licensing Manager
King's College London
melissa.rubock@kcl.ac.uk
Inventors:
Richard Hughes
Norman Gregson
GaI-Ping Zhang
Keywords:
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