Reagent Name
Mouse anti-human integrin alpha 2b (CD41) antibody
Immunogen
Human platelet membranes
Relevance
Integrin alpha 2b is also known as glycoprotein IIb and in a complex with the integrin beta 3 subunit forms the receptor for fibrinogen, fibronectin and von Willebrand Factor on activated platelets. The antibody activates platelets under stirring conditions and inhibits at higher doses . The antibody inhibits binding of fibrinogen, fibronectin and vWF in static adhesion assays and inhibits binding of soluble fibrinogen and fibronectin to ADP activated platelets.
Cross reactivity
Also reacts with baboon integrin alpha 2b.
Specificity
Epitope not mapped. The antibody inhibits binding of disintegrins to activated human platelets
Tested Applications
Flow cytometry, immunoprecipitation
Raised in
Mouse
Clonality
Monoclonal
Isotype
IgG1
References