Human Thyroglobulin Monoclonal Antibody - Clone 1D4

Research tool for

  • ELISA
  • Radioimmunoassay
  • In vivo imaging

 

Thyroglobulin is a large iodinated glycoprotein which is produced by the thyroid gland, functioning as a prohormone in the synthesis of thyroxine (T4) and triiodothyronine (T3).  Levels of serum thyroglobulin are elevated in a variety of thyroid diseases, such as Grave’s disease (goiter), subacute thyroiditis and differentiated thyroid carcinoma.

 

Product Type

Hybridoma for monoclonal antibody


Immunogen

Purified human thyroglobulin


Cross Reactivity

Cross-reacts with baboon.  Does not cross react with sheep, pig, bovine, mouse, chicken or rabbit thyroglobulin


Specificity

Detects both native and denatured human thyroglobulin


Raised in

Mouse


Isotype

IgG1

 

References

  1. Shepherd PS, Lazarus CR, Mistry RD and Maisey MN. 1985.  Detection of thyroid tumour using a monoclonal 123I anti-thyroglobulin antibody.  Eur. J. Nucl. Med. 10: 291-295.
  2. Chan, CTJ, Byfield, TGH, Himsowrth RL and Shepherd PS. 1987.  Human autoantibodies to thyroglobulin are directed towards a restricted number of human specific epitopes. Clin Exp. Immunol. 70: 516-523.
Patent Information:
For Information, Contact:
Melissa Rubock
IP & Licensing Manager
King's College London
melissa.rubock@kcl.ac.uk
Inventors:
Philip Shepherd
Keywords:
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