Search Results - philip+shepherd

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Human Thyrotrophin Receptor Monoclonal Antibody - Clone 2C11

The human thyrotrophin receptor (TSHR) is found primarily in epithelial cells of thyroid follicles where it induces (by cAMP) the phospholipase C and protein kinase A signal transduction pathways. TSHR is the major pathogenic autoantigen in human autoimmune thyroid Graves’ disease.LanesTSHRGlycosylated TSHRTSHR - GSTResidues 125-369 TSHR - GSTProduct...

Published: 11/22/2016 | Updated: 5/8/2014 | Inventor(s): Philip Shepherd

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Category(s): Research Tools - Membrane receptors

Human Complement C1q Monoclonal Antibody - Clone IA4

Research tool for:ImmunohistochemistryIsolation of C1q complexesC1q is a sub-component of the first complement component C1. C1q binds to IgG and IgM immune complexes, this activates C1r and C1s, which are also bound to C1q and so initiates the classical pathway of complement activation. C1q deficiencies are observed in agammaglobulinemia, acute glomerular...

Published: 11/22/2016 | Updated: 5/8/2014 | Inventor(s): Philip Shepherd

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Category(s): Research Tools - Lymphocyte signalling

Human Thyrotrophin Receptor Monoclonal Antibody - Clone 4C1

Research tool forWestern blottingImmunoprecipitationFlow cytometryImmunohistochemistry (frozen section)Inhibits binding of TSH to TSH receptor by 70-80%.The human thyrotrophin receptor (TSHR) is found primarily in epithelial cells of thyroid follicles where it induces (by cAMP) the phospholipase C and protein kinase A signal transduction pathways. ...

Published: 11/22/2016 | Updated: 5/8/2014 | Inventor(s): Philip Shepherd, Alan Johnstone

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Category(s): Research Tools - Membrane receptors

Human Thyrotrophin Receptor Monoclonal Antibody - Clone 3B12

Research tool for:Immunoblotting Immunoprecipitation Flow cytometry Immunohistochemistry (frozen section)Product TypeHybridoma for monoclonal antibodyImmunogenBacterially expressed extracellular domain (residues 1-415) of human TSHR fused to GSTCross ReactivityCross-reacts with human and theoretically with rat, pig, sheep, mouse, dog, catSpecificityDetects...

Published: 11/22/2016 | Updated: 5/8/2014 | Inventor(s): Philip Shepherd

Keywords(s):

Category(s): Research Tools - Membrane receptors

Human Thyroglobulin Monoclonal Antibody - Clone 1D4

Research tool forELISARadioimmunoassayIn vivo imagingThyroglobulin is a large iodinated glycoprotein which is produced by the thyroid gland, functioning as a prohormone in the synthesis of thyroxine (T4) and triiodothyronine (T3). Levels of serum thyroglobulin are elevated in a variety of thyroid diseases, such as Grave’s disease (goiter), subacute...

Published: 11/22/2016 | Updated: 5/8/2014 | Inventor(s): Philip Shepherd

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Category(s): Research Tools - Growth factors and hormones