Human Thyrotrophin Receptor Monoclonal Antibody - Clone 3B12

Research tool for:

• Immunoblotting
• Immunoprecipitation
• Flow cytometry
• Immunohistochemistry (frozen section)

Product Type

Hybridoma for monoclonal antibody

Immunogen

Bacterially expressed extracellular domain (residues 1-415) of human TSHR fused to GST

Cross Reactivity

Cross-reacts with human and theoretically with rat, pig, sheep, mouse, dog, cat

Specificity

Detects residues 336-345 of human TSHR

Raised in

Mouse

Isotype

IgG₁

References

1. Shepherd PS, Da Costa CR, Cridland JC, Gilmore KS, Johnstone AP. 1999.  Monoclonal antibodies that recognize the native human thyrotrophin receptor.  Mol Cell Endocrinol. 149: 197-206.
2. Johnstone, AP, Cridland JC, Da Costa CR, Nussy SS, Shepherd. 2003.  A functional site on the human thyrotrophin receptor – potential therapeutic target in Graves’ disease. Clin Endocrinol. 59: 437-441.