Human Thyrotrophin Receptor Monoclonal Antibody - Clone 2C11

The human thyrotrophin receptor (TSHR) is found primarily in epithelial cells of thyroid follicles where it induces (by cAMP) the phospholipase C and protein kinase A signal transduction pathways.  TSHR is the major pathogenic autoantigen in human autoimmune thyroid Graves’ disease.

Lanes

1. TSHR
2. Glycosylated  TSHR
3. TSHR - GST
4. Residues 125-369 TSHR - GST

Product Type

Hybridoma for monoclonal antibody

Immunogen

Bacterially expressed extracellular domain (residues 1-415 of human TSHR fused to GST)

Cross Reactivity

Cross-reacts with human and theoretically with rat, pig, sheep, mouse, dog, cat

Specificity

Detects residues 352 - 362 of human TSHR. 

Raised in

Mouse

Isotype

IgG₁

References

1. Shepherd PS, Da Costa CR, Cridland JC, Gilmore KS, Johnstone AP. 1999.  Monoclonal antibodies that recognize the native human thyrotrophin receptor.  Mol Cell Endocrinol. 149: 197-206.
2. Johnstone,AP, Cridland JC, Da Costa CR, Nussy SS, Shepherd. 2003.  A functional site on the human thyrotrophin receptor – potential therapeutic target in Graves’ disease. Clin Endocrinol. 59: 437-441.