Search Results - therapeutics

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Candida: Anti-fungal target and immunotherapeutic candidate

The Problem Candida albicans is an opportunistic fungal pathogen, which normally exists as a commensal of the oral cavity and gastrointestinal tracts and frequently causes of superficial vaginitis infections. Moreover, common clinical procedures, such as gastrointestinal surgery, implantation of a central venous catheter or antibiotic...

Published: 11/22/2016 | Updated: 7/3/2014 | Inventor(s): Julian Naglik, Bernhard Hube, David Moyes, Sarah Höfs, Duncan Wilson, Shirley Tang, Jonathan Richardson

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Category(s): Diagnostics, Therapeutics

Targeting acute myeloid leukaemia with Poly-ADP-ribose polymerase (PARP) inhibitors.

SummaryAcute myeloid leukemia (AML) is one of the most common cancers, accounting for about 30,000 new cases each year in the US and EU. Despite recent advances in leukemia research, AML patients are still receiving the same treatment utilised over past few decades, and have a relatively poor prognosis, with 5 year overall survival rate of only about...

Published: 11/22/2016 | Updated: 5/8/2014 | Inventor(s): Eric So, Maria Teresa Esposito

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Category(s): Therapeutics

Anti-CSPG4 antibody for the treatment of melanoma

SummaryA chimeric IgE class anti-CSPG4 antibody has been developed which has demonstrated positive results in vitro and in vivo. The antibody is designed to target immune responses directly against melanoma tumour cells, circumventing the broad immune activatory properties of currently approved immunotherapies.Figure: CSPG4 IgE restricts growth of an...

Published: 11/22/2016 | Updated: 5/8/2014 | Inventor(s): Sophia Karagiannis, Frank Nestle, Andrew Beavil

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Category(s): Therapeutics