Search Results - diagnostics

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Reducing Artifacts in Gradient-Echo MRI using Novel Radiofrequency Pulses

ProblemGradient-echo magnetic resonance imaging (MRI) is used extensively to reveal the structure, and measure the function, of different areas of the body. One particularly exciting application is functional MRI, which can be used to produce maps of brain activity in a subject performing a mental task. Unfortunately signal dropout, caused by differences...

Published: 11/22/2016 | Updated: 11/22/2016 | Inventor(s): Stephen Wastling, Gareth Barker

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Category(s): Medical devices, Diagnostics

Pentraxin 3 (PTX3) oxidation state as Prognosis Marker for Sepsis

Technology Overview:A global, unbiased, cardiac tissue-based proteomics approach for biomarker discovery in a mouse model of sepsis identified pentraxin 3 (PTX-3) as one of the most differentially expressed proteins in cardiac tissue from septic mice. PTX-3 accumulated as an octamer due to disulphide-bond formation, most notably in heart, aorta, kidney...

Published: 11/22/2016 | Updated: 11/22/2016 | Inventor(s): Manuel Mayr, Friederike Cuello

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Category(s): Diagnostics

Predictive Marker for Pre-Term Birth

A small antimicrobial peptide (elafin) predicts risk of developing a short cervix and spontaneous pre-term birth (sPTB) relatively early pregnancy (~ 12-14 weeks of pregnancy)Elevated elafin concentrations in cervico-vaginal fluid (CVF) ) predict cervical shortening from 14 weeks’ and remain high when cervical shortening is first detected. Raised...

Published: 11/22/2016 | Updated: 11/22/2016 | Inventor(s): Rachel Tribe

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Category(s): Diagnostics

Cardiac Myosin Binding Protein C (MyC): Diagnostic Marker of Cardiac Injury

Technology Overview:Elevated levels of Cardiac troponins (cTn) reflect the occurrence of cardiac muscle necrosis and have emerged as the gold standard biomarker and are incorporated into the universal definition of acute myocardial infarction (AMI) Prof Marber's group has identified a cardiac specific biomarker, cardiac myosin-binding protein C (MyC)...

Published: 11/22/2016 | Updated: 11/22/2016 | Inventor(s): Michael Marber, Manuel Mayr, Sebastien Jacquet, Mathias Gautel

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Category(s): Diagnostics

Non-Ionising Imaging

Technology OverviewThe technology uses light at a given near infrared wavelength [NIR] to create a transmission image of dental caries (decay). Healthy hard tissues (enamel, dentine and cementum) tend to ‘guide’ light of this wavelength, leading to a bright image, whereas decay and other inhomogeneities cause optical scattering. This produces...

Published: 11/22/2016 | Updated: 8/5/2014 | Inventor(s): Christopher Longbottom, John Girkin, Simon Poland

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Category(s): Medical devices, Diagnostics

Method to identify bioburden in a root canal following preparation

The ProblemBacteria remaining in the root canal (RC) space at the time of completion of a root canal treatment (RCT) can lead to a persistent or secondary infection, which requires revision of the treatment. Currently, there are no methods in widespread use to detect bacterial presence within the root canal space in a fast and reliable manner. Such...

Published: 11/22/2016 | Updated: 8/5/2014 | Inventor(s): Federico Foschi, Timothy Watson, Frederic Festy, Richard Cook, Garrit Koller, Francesco Mannocci

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Category(s): Medical devices, Diagnostics

Imaging of Unstable Atherosclerotic Plaque via a Novel Magnetic Resonance (MR) Contrast Agent

The ProblemHeart attack (acute myocardial infarction) is predominantly caused by plaque in blood vessels rupturing or eroding. Biological processes found to be associated with plaque progression and destabilization are inflammation, outward vessel wall remodelling and dysfunctional matrix synthesis and degradation. The majority of plaques causing...

Published: 11/22/2016 | Updated: 8/5/2014 | Inventor(s): Rene Botnar, Alkystis Phinikaridou

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Category(s): Diagnostics, Medical devices

Candida: Anti-fungal target and immunotherapeutic candidate

The Problem Candida albicans is an opportunistic fungal pathogen, which normally exists as a commensal of the oral cavity and gastrointestinal tracts and frequently causes of superficial vaginitis infections. Moreover, common clinical procedures, such as gastrointestinal surgery, implantation of a central venous catheter or antibiotic...

Published: 11/22/2016 | Updated: 7/3/2014 | Inventor(s): Julian Naglik, Bernhard Hube, David Moyes, Sarah Höfs, Duncan Wilson, Shirley Tang, Jonathan Richardson

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Category(s): Diagnostics, Therapeutics

Novel, cadmium-free, fluorescent and magnetic nanoparticles suitable for surface functionalisation.

SummaryKing’s Inventors have developed a robust method for the synthesis of water soluble, multicoloured fluorescent-magnetic nanoparticles which do not involve the use of quantum dots, with their associated potential toxicity issues. These lipid encapsulated nanoparticles are made from well characterised, widely available conjugated polymers...

Published: 11/22/2016 | Updated: 5/8/2014 | Inventor(s): Mark Green, Philip Howes

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Category(s): Physical Sciences, Research Tools - Imaging, Diagnostics